Kisspeptin-10
Kisspeptin-10 is a key neuropeptide that stimulates gonadotropin-releasing hormone (GnRH) secretion—making it essential for labs studying reproductive-axis control, hormone release dynamics, and neuroendocrine feedback loops. In both cell culture and rodent models, Kisspeptin-10 provokes clear, time-locked GnRH and LH surges without off-target hormone effects. Each 10 mg vial is USA-manufactured, HPLC-verified to ≥ 99% purity, and endotoxin-screened (< 0.1 EU/mg), delivering reproducible results for your hypothalamic–pituitary–gonadal research.
⚠️ Important Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
Kisspeptin-10
KEY HIGHLIGHTS
GnRH Release Modeling
Evokes pulsatile GnRH secretion in hypothalamic-cell assays, enabling precise study of reproductive-axis triggers.
LH Surge Profiling
In rodent pituitary-slice models, induces luteinizing hormone (LH) peaks—ideal for ovulation and endocrine-feedback research.
Neuroendocrine Feedback
Facilitates mapping of kisspeptin–GnRH–LH loops, supporting studies of hormonal homeostasis and feedback inhibition.
Sexual Maturation Assays
Models puberty-onset pathways in preclinical juvenile rodent protocols, informing developmental endocrinology research.
Metabolic-Reproductive Crosstalk
Probes how energy-balance signals (e.g., leptin) interact with kisspeptin pathways in combined metabolism–reproduction studies.
Easy Handling & Storage
Reconstitute in Sterile Water for Injection (SWFI) or Bacteriostatic Water; store powder at – 20 °C and solution at 2–8 °C for up to 7 days.
What Is Kisspeptin-10 Peptide?
Kisspeptin-10 is a 10-amino-acid fragment of the full kisspeptin protein, acting as a potent activator of the kisspeptin receptor (GPR54) on hypothalamic neurons. In research, Kisspeptin-10 peptide is used to trigger GnRH release, map the hypothalamic–pituitary–gonadal (HPG) axis, and study how reproductive hormones are synchronized.
Why Choose Kisspeptin-10?
Researchers choose Kisspeptin-10 when they need precise control over reproductive-axis activation. Its rapid, reproducible induction of GnRH and subsequent LH release—even in isolated tissue or cell models—makes it indispensable for studying fertility signals, puberty mechanisms, and endocrine feedback. Manufactured under ISO-certified conditions and verified to ≥ 99% purity, Kisspeptin-10 ensures consistent performance across all neuroendocrine protocols.
What Sets Kisspeptin-10 Apart?
Unlike broader neuropeptide preparations, Kisspeptin-10 offers single-axis specificity—directly activating GPR54 without engaging other hypothalamic receptors. Its short sequence and high receptor affinity yield clean, time-locked hormone pulses, allowing researchers to dissect the kinetics of GnRH release, LH surge timing, and downstream steroidogenesis with unmatched precision.
Kisspeptin-10 FAQs
What is Kisspeptin-10 used for in research?
To study GnRH release, LH surge dynamics, and HPG-axis feedback in cell and animal models.
How quickly does Kisspeptin-10 trigger GnRH?
GnRH peaks occur within 5–15 minutes in hypothalamic-cell assays.
What benefits does Kisspeptin-10 offer for reproductive studies?
Enables controlled stimulation of puberty-onset pathways, ovulation models, and hormone feedback loops.
What concentration is typical for in vitro Kisspeptin-10?
Commonly 10–100 nM, adjusted per cell type and experimental design.
Can Kisspeptin-10 induce LH surges in rodents?
Yes—rodent pituitary-slice and in vivo protocols show robust LH peaks following Kisspeptin-10 dosing.
How is Kisspeptin-10 reconstituted?
Dissolve in SWFI or BAC water per protocol and gently mix until fully solubilized.
What storage conditions are required?
Store lyophilized at – 20 °C; keep reconstituted solution at 2–8 °C and use within 7 days.
Does Kisspeptin-10 interact with metabolic signals?
Used to probe leptin–kisspeptin crosstalk, examining how energy balance affects reproductive hormone release.
Is Kisspeptin-10 approved for clinical use?
No—this peptide is strictly for research use only, not for therapeutic or veterinary applications.
Where can I buy Kisspeptin-10 peptide?
Real Peptides offers ISO-certified, USA-manufactured Kisspeptin-10 (10 mg), ≥ 99% purity, and low endotoxin—available for research use only.