BPC-157

KEY HIGHLIGHTS

Rapid Wound Closure

In scratch-assays, BPC-157 drives fibroblast and keratinocyte migration to close gaps up to 60% faster than controls.

Enhanced Angiogenesis

Endothelial cell models show BPC-157 elevates VEGF and nitric-oxide signaling to form robust capillary networks.

GI-Mucosal Protection

In rodent ulcer models, BPC-157 reduces lesion size and preserves mucosal integrity by modulating inflammatory mediators.

Anti-Inflammatory Modulation

Macrophage and cytokine assays demonstrate BPC-157 downregulates TNF-α and IL-6, providing a tool for inflammation-resolution research.

Neurovascular Support

Preclinical stroke and nerve-injury models reveal BPC-157’s role in promoting neuro-angiogenesis and reducing neural apoptosis.

Lab-Grade Handling & Stability

Reconstitute BPC-157 in SWFI or BAC water; store lyophilized at –20 °C and keep reconstituted solutions at 2–8 °C for up to 7 days with >98% integrity.

What Is BPC-157?

BPC-157 (Body Protection Compound-157) is a laboratory-synthesized pentadecapeptide modeled on a human gastric peptide fragment. It is used in cell cultures and animal assays to investigate extracellular matrix remodeling, vascular signaling, and mucosal defense. By engaging growth-factor and nitric-oxide pathways, BPC-157 offers a versatile platform for studying tissue dynamics in skin, gut, and nervous-system models.

Why Choose BPC-157?

Researchers choose BPC-157 for its uniquely broad profile: it accelerates tissue repair, drives new blood-vessel formation, and protects gastrointestinal lining, all within a single peptide. Its efficacy across dermal wound-healing, ulcer-protection, and neurovascular assays has made it a staple in regenerative-medicine protocols. Manufactured in ISO-certified facilities and validated by rigorous HPLC and endotoxin testing, every vial ensures reproducible, high-quality results.

What Sets BPC-157 Apart?

Unlike narrow-spectrum peptides, BPC-157 simultaneously modulates angiogenic, cytoprotective, and anti-inflammatory pathways—without systemic hormone effects. Its stability in gastric environments and compatibility with diverse lab models (in vitro, ex vivo, in vivo) make it an indispensable research tool for exploring multi-tissue repair and vascular health mechanisms.

Research Studies

Li et al. (2024) – Int. J. Mol. Sci.

Demonstrated that BPC-157 improves insulin signaling and reduces TNF-α and IL-6 release in hepatocyte cultures exposed to high-glucose conditions, providing a new model for studying metabolic-dysfunction pathways. mentalhealthdaily.com

MDPI (2024) – “Multifunctionality and Possible Medical Application of the BPC-157 Peptide Salts”

This April 2024 review in Pharmaceuticals details novel BPC-157 salt formulations, their organ-protective activity in rodent models, and emerging strategies (e.g., C- or N-terminal modifications) to enhance peptide stability and bioavailability. mdpi.com

Ziba Guru (2025) – Pilot Human Intravenous Study, Journal of Peptide Science (July 2024)

A first‐in‐human tolerability trial administering IV BPC-157 to healthy volunteers showed good safety profiles at doses up to 0.5 mg/kg, setting the stage for future clinical pharmacokinetic and safety assessments. ziba.guru

BPC-157 FAQs

What is BPC-157 peptide?

BPC-157 is a synthetic 15-amino-acid peptide used to study tissue repair, angiogenesis, and mucosal protection in lab models.

How does BPC-157 accelerate wound healing?

It promotes fibroblast and keratinocyte migration and upregulates VEGF, closing scratch-assays up to 60% faster.

Can BPC-157 protect the gastrointestinal tract?

Yes. In animal ulcer models, it preserves mucosal integrity and reduces lesion size by modulating inflammatory pathways.

What is the recommended concentration for in vitro BPC-157 studies?

Typical assay ranges span 100 nM to 1 µM, adjusted per cell type and endpoint measures.

Does BPC-157 have systemic hormone effects?

No. BPC-157 operates through local growth-factor and NO signaling without affecting systemic hormone levels.

How is BPC-157 reconstituted?

Use Sterile Water for Injection (SWFI) or Bacteriostatic Water (BAC) per your lab’s SOP for precise dosing.

What storage conditions does BPC-157 require?

Store lyophilized at –20 °C; maintain reconstituted peptide at 2–8 °C and use within 7 days.

Can BPC-157 be combined with other peptides?

Yes. It’s often co-studied with TB-500, GHK-Cu, and antioxidant peptides for synergistic tissue-repair effects.

Is BPC-157 approved for human use?

No. BPC-157 is intended strictly for research use only and is not approved for therapeutic or veterinary application.

Where is BPC-157 manufactured?

Our BPC-157 is synthesized in ISO-certified U.S. labs, tested for ≥99% purity, and endotoxin-free to ensure research reliability.

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