FOXO4-DRI
FOXO4-DRI is a synthetic peptide designed to disrupt the interaction between FOXO4 and p53, prompting targeted clearance of senescent cells in cell culture and animal models. Researchers use FOXO4-DRI to study cellular aging, senescence-associated secretory phenotype (SASP) modulation, and longevity signaling. Each 10 mg vial is USA-manufactured and tested to ≥99% purity, with endotoxin <0.1 EU/mg—ideal for your peptide-driven aging research.
⚠️ Important Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
FOXO4-DRI
KEY HIGHLIGHTS
Selective Senescent-Cell Clearance
FOXO4-DRI binds FOXO4, freeing p53 to trigger apoptosis specifically in β-galactosidase–positive senescent cells, modeling targeted cell-cleanup protocols.
SASP Reduction
Treatment with FOXO4-DRI lowers levels of inflammatory SASP factors (IL-6, IL-8) in fibroblast cultures, providing a tool to study inflammation in aging.
Longevity Pathway Activation
In endothelial and epithelial assays, FOXO4-DRI enhances markers of healthy mitochondrial function and stress resistance, supporting lifespan-extension research.
DNA Damage Response Modulation
FOXO4-DRI influences p53-mediated pathways to balance DNA repair and apoptosis in cell-stress models, aiding studies of genotoxic resilience.
Dose-Response Precision
Concentrations from 100 nM to 5 µM reveal FOXO4-DRI’s senolytic potency and define optimal windows for protocol design.
Lab-Friendly Prep & Storage
Reconstitute in Sterile Water for Injection (SWFI) or Bacteriostatic Water (BAC). Store lyophilized at –20 °C; keep reconstituted solutions at 2–8 °C and use within 7 days to preserve ≥98% integrity.
What Is FOXO4-DRI?
FOXO4-DRI is a “designed-retro-inverso” peptide that mimics the FOXO4 protein’s binding region in reverse sequence and D-amino-acid form. This design enables it to enter cells and competitively displace FOXO4 from p53, selectively driving senescent cells into programmed cell death. It’s used in preclinical aging and tissue-regeneration models to study the impact of senescent-cell removal on tissue function.
Why Choose FOXO4-DRI?
Researchers choose FOXO4-DRI for its unmatched ability to target senescent cells without harming normal proliferating cells. Its retro-inverso design delivers enhanced stability in culture and in vivo, while rigorous purity testing ensures reproducible results. FOXO4-DRI provides a precise, scalable approach for labs exploring anti-aging, regenerative medicine, and cell-stress response protocols.
What Sets FOXO4-DRI Apart?
Unlike broad-spectrum senolytic compounds, FOXO4-DRI offers molecular specificity by disrupting a single protein–protein interaction (FOXO4:p53) to induce apoptosis only in senescent cells. Its D-amino-acid retro-inverso configuration grants exceptional resistance to proteolytic degradation, ensuring consistent activity throughout your experiments. FOXO4-DRI is the go-to peptide for clean, targeted senescence research.
FOXO4-DRI FAQs
What is FOXO4-DRI peptide?
FOXO4-DRI is a designed-retro-inverso peptide that disrupts the FOXO4:p53 interaction to selectively clear senescent cells in preclinical aging models.
How does FOXO4-DRI work in cell culture?
It enters cells, displaces FOXO4 from p53, and triggers apoptosis only in β-galactosidase–positive senescent cells, preserving healthy cells.
What research applications use FOXO4-DRI?
Commonly used in studies of cellular senescence, SASP (senescence-associated secretory phenotype) modulation, and longevity-pathway assays.
How do I reconstitute FOXO4-DRI for lab use?
Dissolve in Sterile Water for Injection (SWFI) or Bacteriostatic Water (BAC) according to your protocol, then gently mix until fully solubilized.
What storage conditions are required for FOXO4-DRI?
Store lyophilized FOXO4-DRI at –20 °C; keep reconstituted solutions at 2–8 °C and use within 7 days to maintain ≥ 98% peptide integrity.
What concentration range is typical for FOXO4-DRI assays?
In vitro protocols often span 100 nM to 5 µM, with dose–response curves used to pinpoint optimal senolytic activity.
Can FOXO4-DRI be combined with other peptides?
Yes. Researchers frequently pair it with antioxidants or regenerative peptides (e.g., Epithalon, GHK-Cu) to study combined anti-aging effects.
Is FOXO4-DRI safe for non-senescent cells?
Designed for specificity, FOXO4-DRI triggers apoptosis only in senescent cells, leaving proliferating cells largely unaffected in controlled studies.
Is FOXO4-DRI approved for therapeutic use?
No—FOXO4-DRI is strictly for research use only and is not approved for human or veterinary applications.
Where can I buy high-purity FOXO4-DRI?
Real Peptides offers FOXO4-DRI that’s USA-manufactured, ISO-certified, tested to ≥ 99% purity, and endotoxin-screened for reliable research outcomes.