GHRP-2

KEY HIGHLIGHTS

Potent GH Pulses

GHRP-2 peptide induces clear, reproducible GH spikes in rodent and cell-based assays, enabling precise study of downstream effects.

IGF-1 Pathway Engagement

Downstream upregulation of IGF-1 in hepatocyte and muscle-cell cultures supports investigations of anabolic-signal cascades.

Lean-Tissue Modeling

In muscle-cell assays, GHRP-2 enhances markers of protein synthesis (e.g., myosin heavy chain), modeling anabolic outcomes.

Endocrine-Feedback Insights

Short half-life (~45 minutes) provides temporal control to dissect somatostatin-mediated inhibition and receptor-desensitization dynamics.

Minimal Off-Target Hormones

Compared to GHRH analogs, GHRP-2 triggers GH without significant cortisol or prolactin elevation, yielding “clean” endocrine-axis data.

Easy Prep & Storage

Reconstitute in Sterile Water for Injection (SWFI) or Bacteriostatic Water (BAC), store powder at – 20 °C, and keep solution at 2–8 °C (use within 7 days).

What Is GHRP-2 Peptide?

GHRP-2 is a synthetic six-amino-acid peptide that binds the ghrelin receptor (GHS-R1a) on pituitary somatotrophs to provoke pulsatile growth-hormone (GH) release. In research contexts, GHRP-2 peptide is used to model anabolic signaling, IGF-1 dynamics, and pituitary feedback under tightly controlled laboratory conditions, making it a cornerstone reagent for endocrine-axis studies.

Why Choose GHRP-2?

Researchers choose GHRP-2 when they need a highly specific GH-secretagogue with minimal hormonal “noise.” Its ability to elicit robust, repeatable GH pulses—without significant cortisol or prolactin spikes—provides clean, interpretable data on lean-tissue anabolism, IGF-1–mediated growth, and feedback regulation. Manufactured under ISO-certified conditions and verified to ≥ 99% purity (HPLC) with stringent endotoxin screening, GHRP-2 delivers reproducible, high-fidelity results in both in vitro and in vivo studies.

What Sets GHRP-2 Apart?

Unlike broader-acting secretagogues, GHRP-2 offers single-axis specificity—directly targeting the ghrelin receptor to release GH without collateral activation of other hormonal pathways. Its rapid onset and short duration of action give researchers temporal precision to map GH pulses, IGF-1 kinetics, and somatostatin feedback loops. This combination of potency, specificity, and clean endocrine profile makes GHRP-2 the go-to peptide for high-resolution GH-axis and anabolic-research protocols.

GHRP-2 FAQs

What is GHRP-2 peptide used for?

It’s used to study pulsatile GH release, IGF-1 activation, and anabolic signaling in preclinical models.

How does GHRP-2 trigger growth-hormone release?

By binding the GHS-R1a (ghrelin) receptor on pituitary cells, inducing rapid GH spikes.

What dose of GHRP-2 is typical in vitro?

Researchers often use 100 nM–1 µM, adjusted per cell type and assay.

Can GHRP-2 raise IGF-1 levels?

Yes—GH pulses from GHRP-2 lead to downstream IGF-1 upregulation in liver and muscle assays.

What is the half-life of GHRP-2 peptide?

Approximately 45 minutes, allowing precise temporal studies of endocrine feedback.

Does GHRP-2 affect cortisol or prolactin?

No—its selective ghrelin-receptor action yields minimal off-target hormone elevation.

How is GHRP-2 reconstituted?

Dissolve in Sterile Water for Injection (SWFI) or Bacteriostatic Water (BAC), then mix until clear.

What storage conditions are required?

Store lyophilized at – 20 °C; keep reconstituted solution at 2–8 °C and use within 7 days.

Can GHRP-2 be combined with GHRH analogs?

Yes—often co-administered with CJC-1295 No DAC or sermorelin to study synergistic GH-axis effects.

Where can I buy research-grade GHRP-2 peptide?

Real Peptides offers ISO-certified, USA-manufactured GHRP-2 (10 mg), ≥ 99% purity, and low endotoxin—available for research use only.

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