IGF-1 LR3
IGF-1 LR3 is a long-acting analog of insulin-like growth factor-1 (IGF-1) engineered for extended receptor binding and enhanced bioactivity. Ideal for labs probing cell proliferation, protein synthesis, and metabolic regulation, IGF-1 LR3 delivers sustained IGF-1 receptor activation in both cell-culture and small-animal models. Each 1 mg vial is USA-manufactured, HPLC-verified to ≥ 99% purity, and endotoxin-screened (< 0.1 EU/mg), ensuring reproducible, high-precision data for your IGF-1 research.
⚠️ Important Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
IGF-1 LR3
KEY HIGHLIGHTS
Extended IGF-1 Receptor Activation
IGF-1 LR3’s modified structure prolongs receptor binding, enabling sustained signaling windows in proliferation assays.
Cell-Growth & Proliferation Modeling
Drives robust increases in cell-cycle markers (Cyclin D1, PCNA) in fibroblast and myoblast cultures.
Protein-Synthesis Enhancement
Upregulates mTOR and S6K phosphorylation—key readouts for anabolic-signal studies in muscle-cell assays.
Metabolic-Pathway Insights
Modulates glucose-uptake and lipid-metabolism genes (GLUT4, PPARγ) in adipocyte and hepatocyte models.
Straightforward Prep & Storage
Reconstitute in sterile or bacteriostatic water; store lyophilized at – 20 °C and solution at 2–8 °C for up to 7 days.
In Vivo Pharmacodynamics
In rodent dosing, IGF-1 LR3 yields prolonged IGF-1 plasma levels (≥ 24 h), ideal for long-term signaling studies.
What Is IGF-1 LR3 Peptide?
IGF-1 LR3 is a synthetic analog of human insulin-like growth factor-1 in which the first three amino acids are removed and an arginine added at position 3. This modification greatly extends its half-life and receptor affinity. In research settings, IGF-1 LR3 is used to examine IGF-1 receptor dynamics, anabolic signaling, and metabolic regulation with greater temporal control than native IGF-1.
Why Choose IGF-1 LR3?
Researchers select IGF-1 LR3 when they require prolonged and potent IGF-1 activity without rapid degradation. Its enhanced stability and high receptor affinity produce consistent activation of downstream pathways—mTOR, MAPK, and PI3K/Akt—critical for studies of cell proliferation, protein synthesis, and glucose metabolism. Manufactured under ISO-certified conditions and verified to ≥ 99% purity, IGF-1 LR3 ensures rigorous reproducibility across both in vitro and in vivo protocols.
What Sets IGF-1 LR3 Apart?
Unlike native IGF-1, IGF-1 LR3’s structural tweaks confer a three- to five-fold longer half-life and increased receptor binding, making it uniquely suited for sustained signaling experiments. Its ability to maintain elevated IGF-1 levels for over 24 hours in animal models eliminates the need for multiple daily doses, simplifying study design and reducing variability. This precision makes IGF-1 LR3 the go-to reagent for high-impact anabolic and metabolic-pathway research.
IGF-1 LR3 FAQs
What is IGF-1 LR3 peptide used for?
To study sustained IGF-1 receptor activation, cell proliferation, and anabolic signaling in research models.
How does IGF-1 LR3 differ from native IGF-1?
It has a longer half-life and stronger receptor affinity due to a modified amino-acid sequence, enabling prolonged signaling.
What concentration is typical in vitro?
Common in vitro dosing ranges from 10 to 100 ng/mL, adjusted per cell type and endpoint.
Can IGF-1 LR3 drive muscle-cell protein synthesis?
Yes—upregulates mTOR and S6K phosphorylation in myoblast assays, modeling anabolic effects.
What in vivo dosing is used in rodent studies?
Researchers often use 0.01–0.1 mg/kg, resulting in elevated IGF-1 levels for 24+ hours.
How is IGF-1 LR3 reconstituted?
Dissolve in Sterile Water for Injection or Bacteriostatic Water, gently mix until clear, then use immediately or store at 2–8 °C.
What storage conditions are required?
Store lyophilized at – 20 °C; keep reconstituted solution at 2–8 °C and use within 7 days.
Does IGF-1 LR3 affect glucose uptake?
Yes—it upregulates GLUT4 expression in adipocyte and muscle models, aiding metabolic-pathway research.
Is IGF-1 LR3 approved for human use?
No—IGF-1 LR3 is strictly for research use only, not for clinical or veterinary applications.
Where can I buy IGF-1 LR3 peptide?
Real Peptides offers ISO-certified, USA-manufactured IGF-1 LR3 (1 mg) at ≥ 99% purity and low endotoxin—available for research use only.