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Liquid Spray

Semax Liquid Spray — 45mg

Q: What is Semax liquid spray used for in research?

Semax liquid spray is used in research to study cognitive enhancement, BDNF/NGF signaling, neuroprotection in stroke and ischemia models, and monoamine system modulation. It is a synthetic heptapeptide derived from ACTH(4-10), developed in Russia and supplied by Real Peptides as a 45mg multi-dose liquid spray for laboratory research.

Q: How does Semax work?

Semax works by rapidly upregulating BDNF (brain-derived neurotrophic factor), NGF (nerve growth factor), and the TrkB receptor in the hippocampus and frontal cortex. It also modulates serotonergic and dopaminergic systems and inhibits enkephalin-degrading enzymes. Research shows these mechanisms produce cognitive enhancement and neuroprotection in preclinical models.

Q: What has Semax research documented?

Research has documented five core documented findings: (1) rapid BDNF and NGF elevation in the hippocampus, (2) cognitive performance improvements in learning assays within 15 minutes of intranasal administration, (3) neuroprotection in cerebral ischemia models, (4) serotonin and dopamine system modulation, and (5) inhibition of enkephalin degradation supporting endogenous opioid pathway research.

Q: How fast does Semax liquid spray work?

Research shows Semax reaches the central nervous system within 15–30 minutes of intranasal administration via the olfactory pathway. Rodent studies have measured cognitive task improvements 15 minutes after treatment, and BDNF/TrkB elevation is measurable within hours.

Q: How is Semax supplied?

As a pre-solubilized solution in a multi-use spray bottle, HPLC-verified to ≥99% purity with a per-lot certificate of analysis.

Q: Is Semax FDA approved?

No. Semax is not FDA-approved in the United States. It is approved in Russia for stroke, transient ischemic attack, cognitive disorders, and optic nerve indications, and appears on the Russian List of Vital and Essential Drugs. Real Peptides supplies Semax liquid spray strictly for laboratory research use.

Q: What is the difference between Semax and Selank?

Both are Russian-developed heptapeptides with a shared Pro-Gly-Pro stability extension. Semax is derived from ACTH(4-10) and is primarily studied for cognitive and neuroprotective activity. Selank is derived from tuftsin and is primarily studied for anxiolytic and immunomodulatory activity. Researchers frequently pair the two peptides for combined cognitive-anxiolytic study designs.

Q: Is Semax better than N-Acetyl Semax?

Semax and N-Acetyl Semax differ in structural stability. N-Acetyl Semax includes an acetyl modification that some research literature describes as providing extended stability in solution. Standard Semax, as supplied by Real Peptides, is the most extensively studied form in the published research literature and is the reference peptide for Semax research protocols.

Q: Can Semax be stacked with other peptides in research?

Yes. Semax is most frequently co-studied with Selank (complementary cognitive-anxiolytic pairing), and across broader cognitive and neurological peptide panels. Its clean BDNF/TrkB mechanism makes it an anchor peptide in neuroplasticity-focused study designs.

Q: How should Semax liquid spray be stored?

Store Semax liquid spray at 2–8°C (refrigerated), protected from light. Do not freeze. When stored correctly, the formulation maintains ≥98% integrity throughout its shelf life.

$200.00

Finished in the USA

Semax liquid spray is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH(4-10), studied in research for cognitive, neuroprotective, and BDNF-modulatory effects. Each bottle is HPLC-verified to ≥99% purity, endotoxin-screened (<0.1 EU/mg), and formulated for laboratory research.

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Semax Liquid Spray — 45mg · 45mg

$200.00

Recommended with this order

Frequently paired with this compound by other researchers.

Selank Liquid Spray — 45mg$200.00

45mg

MOTS-c Liquid Spray$200.00

25mg

For Research Use Only. Not for human consumption or therapeutic treatment.

AboutLab reportSpecificationsQuestions

Finished in the USA

What Is Semax Peptide?

Semax is a synthetic seven-amino-acid peptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the 4–10 fragment of adrenocorticotropic hormone (ACTH), with a Pro-Gly-Pro tail added for metabolic stability. Developed at the Russian Academy of Sciences, Semax retains the neurotrophic signaling of ACTH without hormonal activity — making it one of the most extensively studied cognitive-research peptides in the literature. Semax liquid spray research spans cognitive enhancement, neuroprotection, stroke recovery models, and aging-related cognitive decline.

Why Choose Semax Liquid Spray?

Researchers choose Semax liquid spray when studying cognitive enhancement, neuroplasticity, BDNF signaling, and recovery from neurological injury. Intranasal delivery is the most documented research route for Semax, with published studies showing BDNF and TrkB elevation within minutes of administration via olfactory pathway uptake. and HPLC-verified at ≥99% purity with endotoxin <0.1 EU/mg, Real Peptides Semax liquid spray delivers clean, reproducible experimental data for neuroscience and cognition research.

What Sets Semax Apart?

Semax engages the BDNF/TrkB signaling system directly — rapidly upregulating both the growth factor and its receptor in a single administration. That dual action is what makes Semax a standout research tool for neuroplasticity, learning and memory assays, and ischemic injury models, where downstream effects can be measured within hours rather than days. Many researchers pair Semax with Selank liquid spray to combine cognitive and anxiolytic research endpoints in the same study design.

Research observations

BDNF & NGF Elevation

A single intranasal Semax application rapidly increases BDNF, NGF, and TrkB receptor expression in the hippocampus and frontal cortex in rodent models.

Cognitive Performance Modeling

Semax improves performance in rat passive-avoidance, conditioned-reflex, and learning assays, often within 15 minutes of intranasal administration.

Neuroprotection Under Ischemia

In rodent cerebral ischemia and photothrombosis models, Semax reduces infarction size and preserves cognitive function post-injury.

Serotonin & Dopamine Signaling

Semax modulates monoamine metabolism, potentiates dopaminergic activity, and has been studied as a tool for attention and mood research.

Enkephalin System Interaction

Semax inhibits enzymes involved in enkephalin degradation — a shared property with Selank that supports endogenous opioid pathway research.

Lab-Friendly Format

Pre-formulated liquid spray — no reconstitution required. Store at 2–8°C, protect from light. Maintains ≥98% integrity throughout shelf life.

Tested 22-Jul-2026

Kovera · 2 reports

1 earlier

CompoundSemax Liquid Spray — 45mg

Research areaLiquid Spray

FormatLiquid spray

Sizes45mg

Reconstituted shelf life30 days at 2–8°C

Independent laboratoryFreedom Diagnostics and Kovera

Lab reports on file2 reports

Ships fromSaint Petersburg, FL and California

DispatchWithin 24 hours

Semax liquid spray is used in research to study cognitive enhancement, BDNF/NGF signaling, neuroprotection in stroke and ischemia models, and monoamine system modulation. It is a synthetic heptapeptide derived from ACTH(4-10), developed in Russia and supplied by Real Peptides as a 45mg multi-dose liquid spray for laboratory research.

Semax works by rapidly upregulating BDNF (brain-derived neurotrophic factor), NGF (nerve growth factor), and the TrkB receptor in the hippocampus and frontal cortex. It also modulates serotonergic and dopaminergic systems and inhibits enkephalin-degrading enzymes. Research shows these mechanisms produce cognitive enhancement and neuroprotection in preclinical models.

Research has documented five core documented findings: (1) rapid BDNF and NGF elevation in the hippocampus, (2) cognitive performance improvements in learning assays within 15 minutes of intranasal administration, (3) neuroprotection in cerebral ischemia models, (4) serotonin and dopamine system modulation, and (5) inhibition of enkephalin degradation supporting endogenous opioid pathway research.

Research shows Semax reaches the central nervous system within 15–30 minutes of intranasal administration via the olfactory pathway. Rodent studies have measured cognitive task improvements 15 minutes after treatment, and BDNF/TrkB elevation is measurable within hours.

As a pre-solubilized solution in a multi-use spray bottle, HPLC-verified to ≥99% purity with a per-lot certificate of analysis.

No. Semax is not FDA-approved in the United States. It is approved in Russia for stroke, transient ischemic attack, cognitive disorders, and optic nerve indications, and appears on the Russian List of Vital and Essential Drugs. Real Peptides supplies Semax liquid spray strictly for laboratory research use.

Both are Russian-developed heptapeptides with a shared Pro-Gly-Pro stability extension. Semax is derived from ACTH(4-10) and is primarily studied for cognitive and neuroprotective activity. Selank is derived from tuftsin and is primarily studied for anxiolytic and immunomodulatory activity. Researchers frequently pair the two peptides for combined cognitive-anxiolytic study designs.

Semax and N-Acetyl Semax differ in structural stability. N-Acetyl Semax includes an acetyl modification that some research literature describes as providing extended stability in solution. Standard Semax, as supplied by Real Peptides, is the most extensively studied form in the published research literature and is the reference peptide for Semax research protocols.

Yes. Semax is most frequently co-studied with Selank (complementary cognitive-anxiolytic pairing), and across broader cognitive and neurological peptide panels. Its clean BDNF/TrkB mechanism makes it an anchor peptide in neuroplasticity-focused study designs.

Store Semax liquid spray at 2–8°C (refrigerated), protected from light. Do not freeze. When stored correctly, the formulation maintains ≥98% integrity throughout its shelf life.

Real Peptides sells Semax liquid spray in a 45mg multi-dose format, HPLC-verified at ≥99% purity. Presale pricing is $200 ($100 off the $300 MSRP), with orders shipping May 3. Browse our full peptide catalog or view popular peptidesfor related compounds.