Bromantane · Research brief

Bromantane Price for Research: What Drives the Cost

Real Peptides Research TeamEditorial

Updated September 9, 20269 min read

60 WORDS

Short answer

Two suppliers can quote a bromantane price that differs by a factor of ten for material that looks identical sitting in the vial. The powder isn't the variable. The paperwork is. We've spent years sourcing, testing and documenting research compounds, and the pattern holds without exception: the cheapest quote on the page is almost always the one with the thinnest…

Key takeaways

Bromantane price is quoted per gram, not per vial, because bromantane is a small molecule with a molecular weight of roughly 306 g/mol rather than a lyophilised peptide.
Batch scale is the single largest driver of bromantane price, since a full analytical panel costs the same whether the lot is 10 grams or 10 kilograms.
A certificate of analysis without a matching lot number and an attached chromatogram is a marketing document, not an analytical one.
Research grade small molecules are commonly specified at 98% or higher by HPLC, but area percent at one detection wavelength cannot detect impurities that fail to absorb at that wavelength.
Bromantane requires no cold chain and stays stable at room temperature in a sealed light protected container, which removes a cost layer that peptides carry.
Bromantane is research use only, is not an FDA approved drug product, and appears on the World Anti-Doping Agency Prohibited List as a stimulant.
Normalise every quote to cost per milligram before comparing suppliers, or the per gram figures will mislead you.

Two suppliers can quote a bromantane price that differs by a factor of ten for material that looks identical sitting in the vial. The powder isn't the variable. The paperwork is.

We've spent years sourcing, testing and documenting research compounds, and the pattern holds without exception: the cheapest quote on the page is almost always the one with the thinnest analytical file behind it.

What is the price of bromantane for research use?

Bromantane price is normally quoted per gram rather than per vial, and it is driven by synthesis batch scale, documented HPLC purity, and whether third party analytical testing is included in the sale. Documented small batch material typically costs several times more than undocumented bulk powder. Ask for the batch specific certificate of analysis before comparing any two numbers.

The common oversimplification is that bromantane price tracks purity, so a bigger number on the datasheet means cleaner material. It doesn't. Price tracks documentation and batch scale, because printing 99% on a spec sheet costs a supplier nothing. This piece covers what bromantane is actually supplied as, which cost inputs genuinely move the bromantane price, and how to verify a certificate of analysis against the material in hand.

What a supplier actually ships when you order this compound

Bromantane is a small molecule, not a peptide. Chemically it is N-(2-adamantyl)-N-(4-bromophenyl)amine, referred to in older literature as ladasten, an adamantane derivative with the formula C16H20BrN and a molecular weight of roughly 306 g/mol. That single fact changes everything about packaging and pricing. There is no lyophilisation step, no reconstitution with bacteriostatic water, and no cold chain requirement of the kind that governs peptide handling at minus 20 degrees Celsius. It ships as a crystalline powder, typically off white to pale cream, stable at room temperature in a sealed amber container kept away from light and moisture.

Three formats dominate the quotes you'll see:

Pre weighed powder in sealed vials, usually in gram or sub gram increments. This carries the highest bromantane price per gram, because someone weighed, capped, labelled and lot coded every single unit.
Bulk powder in foil sealed pouches, aimed at laboratories running assays at scale. The bromantane price per gram drops sharply here, and so does the handling convenience.
Pre dissolved stock solutions in a carrier such as DMSO for in vitro work, quoted per millilitre at a stated molar concentration rather than per gram.

All of it is research use only. Bromantane is not an FDA approved drug product and is supplied for laboratory research, never for human or veterinary consumption. If a question concerns an animal's health, that belongs with a licensed veterinarian rather than a compound datasheet. Bromantane also appears on the World Anti-Doping Agency Prohibited List as a stimulant, which matters for anyone working inside sports science research.

Where the number on the quote actually comes from

A bromantane price is built from four inputs, and only one of them is the compound itself. Batch scale comes first. A full analytical panel on a single lot costs the supplier roughly the same whether that lot is 10 grams or 10 kilograms, so the per gram figure falls as the batch grows. Synthesis route is second. Bromantane is produced by coupling an adamantane fragment with 4-bromoaniline, and the purity of those starting materials plus the efficiency of the coupling and recrystallisation steps determine how much usable material survives to final product. A low yield route doesn't just produce dirtier powder, it produces less powder per unit of input cost.

Third is analytical burden. HPLC purity, identity confirmation by mass spectrometry, structural confirmation by proton NMR, residual solvent screening and water content by Karl Fischer titration are each a separate paid test. Fourth is documentation depth: whether that testing happened in house or was paid for at an independent laboratory with the raw chromatogram released to the buyer.

Here is the costing mistake we see constantly, and it has nothing to do with overpaying. Researchers compare a bromantane price per gram against a peptide price per vial and conclude the small molecule is expensive. A 5 mg peptide vial and a 1 gram bottle of bromantane are separated by a factor of 200 in mass. Normalise everything to milligrams before you compare anything, or every bromantane price on your shortlist will look irrational.

How to verify purity before money changes hands

A certificate of analysis only means something if it is lot specific. The first filter we apply to every incoming batch across our catalog is blunt: does the lot number printed on the COA match the lot number on the container, and is an actual chromatogram attached rather than a summary table with a percentage typed into it?

A usable COA contains the lot number, the date of analysis, the analytical method named explicitly (HPLC area percent at a stated detection wavelength, for instance), an identity confirmation kept separate from the purity figure, the name of the testing facility, and the raw trace itself. Research grade small molecules are commonly specified at 98% or higher by HPLC, but that figure is close to meaningless without the method behind it, because area percent measured at one wavelength cannot see impurities that don't absorb at that wavelength.

The red flags are consistent. One COA reused across multiple lots. No lot number at all. A purity claim with no identity confirmation. A supplier who will send a certificate but not the chromatogram. Any of those and the bromantane price stops being a bargain and becomes a gamble on an unknown solid.

Independent retesting closes the gap. Sending a small sample to a third party analytical laboratory costs a fraction of a research programme's budget and settles the question permanently. When a compound is held in stock rather than sourced to order, that verification loop is far quicker, because the lot on the shelf is the lot on the COA and dispatch usually happens within a business day.

Bromantane Price: Supplier Tier Comparison

Supplier tiers differ far more in documentation than in the compound itself. This table maps what you typically receive at each tier and how that shifts the bromantane price you're quoted.

Supplier Tier	Documentation You Typically Receive	Where the Quoted Cost Lands	Bottom Line
Bulk chemical broker or marketplace listing	Generic spec sheet, often no lot number, sometimes a COA dated years earlier	Lowest per gram figure available, frequently with a high minimum order quantity	Verification confidence 2/10. Fine for non critical bulk work, unusable where reproducibility matters.
Reseller with in house COA only	Lot referenced COA produced by the seller, purity table without the raw chromatogram	Mid range, usually 2 to 3 times the broker figure	Verification confidence 5/10. Acceptable if the seller will release the trace on request. Walk away if they won't.
Small batch supplier with per lot third party testing	Independent laboratory COA, matching lot number, HPLC chromatogram, separate identity confirmation	Highest per gram figure, reflecting amortised analytics over a smaller batch	Verification confidence 9/10. The only tier where the analytical claim is auditable by a buyer.
Pre dissolved solution vendor	Concentration and carrier stated, rarely a stability or degradation study	Priced per millilitre, so direct comparison to powder requires conversion	Verification confidence 4/10. Convenient for in vitro assays, opaque on the mass you're actually receiving.

What If: Sourcing and Verification Scenarios

What if the COA I received has no lot number on it?

Treat it as no COA at all and request the lot specific document before releasing payment. A certificate without a lot reference cannot be tied to the container in front of you, which means it certifies nothing testable. Suppliers running proper batch records can produce this within minutes because the document is generated per synthesis run. A supplier who stalls or sends the same PDF again is telling you the analytics were never lot linked in the first place.

What if two suppliers quote a bromantane price ten times apart?

Ask both for the chromatogram and the batch size before assuming the expensive one is overcharging. A tenfold gap in bromantane price is almost always explained by amortisation: a kilogram scale lot spreads one analytical panel across a thousand grams, while a 50 gram lot spreads the same cost across fifty. The gap becomes suspicious only when the cheaper supplier also cannot name the testing method or release the raw trace.

What if the powder arrives a different colour than the previous batch?

Stop, photograph it, and request the current lot COA alongside the previous one for comparison. Bromantane is normally an off white to pale crystalline solid, and a noticeable colour shift can indicate residual solvent, oxidative degradation or a different recrystallisation step in the synthesis. Research suggests appearance alone is a poor purity indicator either way, so the COA comparison matters more than the visual check.

What if a supplier only sells in kilogram minimums?

Source from a supplier that stocks smaller documented lots, even at a higher per gram bromantane price. Buying a kilogram to run a gram scale study means the remaining material sits for years, and while bromantane is room temperature stable, no supplier issues an open ended shelf life guarantee on a solid you've already opened and repeatedly exposed to air.

The Unglamorous Truth About Bargain Bin Research Chemicals

Here's the honest answer: at the bottom of the market you are not buying a cheaper compound, you are buying an untested one. Nobody skips HPLC, mass spectrometry and residual solvent screening and then passes the savings along out of generosity. They skip it because testing is the expensive part. When a bromantane price sits well below every documented supplier on the market, the missing money is the missing analytics, and that absence propagates into every result generated from that lot. You cannot correct for an impurity you never measured.

That verification standard is the same one applied across our small batch synthesis work at Real Peptides, where researchers investigating adjacent areas often work with our cognitive function research compounds or the energy, mitochondria and fatigue bundle for laboratory use, each supplied with lot linked documentation.

The bromantane price you pay is really a price on certainty, and certainty is the one thing a chromatogram delivers that a datasheet never can. Undocumented powder isn't cheaper research. It's research with an unmeasured variable baked into every data point that comes out of it. Somewhere down the line that variable will explain a result nobody can reproduce, and by then the lot will be exhausted and the seller will have rotated to a new listing. Buy the paperwork. The compound arrives with it.

References

Peer-reviewed sources on Bromantane indexed in PubMed, listed for research context. Real Peptides supplies Bromantane for laboratory research use only.

Correcting effect of ladasten on variations in the subpopulation composition of T lymphocytes in C57BL/6 mice on the experimental model of an anxious-depressive state. Bulletin of experimental biology and medicine, 2014. PMID 24771370. doi:10.1007/s10517-014-2343-1
[Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types]. Eksperimental'naia i klinicheskaia farmakologiia, 2012. PMID 22834121
Mechanisms of action of ladasten: activation of gene expression for neurotrophins and mitogen-activated kinases. Bulletin of experimental biology and medicine, 2012. PMID 22803074. doi:10.1007/s10517-012-1516-z
Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome. Bulletin of experimental biology and medicine, 2011. PMID 22803040. doi:10.1007/s10517-011-1453-2
[Effect of antiasthenic drug ladasten on the level of cytokines and behavior in experimental model of anxious depression in C57BL/6 male mice]. Eksperimental'naia i klinicheskaia farmakologiia, 2011. PMID 22288152
Time course of histone deacetylase 1 and acetylated H3 and H4 histones in the brain of rats treated with ladasten. Bulletin of experimental biology and medicine, 2011. PMID 22235395. doi:10.1007/s10517-011-1201-7
[Role of the brain dopaminergic and serotoninergic systems in psychopharmacological effects of ladasten and sydnocarb]. Eksperimental'naia i klinicheskaia farmakologiia, 2010. PMID 20369592
[Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015]. Eksperimental'naia i klinicheskaia farmakologiia, 2010. PMID 20408420

Questions

Bromantane price is almost always quoted per gram, because bromantane is a small molecule rather than a lyophilised peptide sold in milligram vials. The figure reflects synthesis batch size, the cost of the analytical panel run on that lot, and whether testing was performed in house or paid for at an independent laboratory. Pre weighed and lot coded vials cost more per gram than bulk foil sealed pouches because the labour and documentation are priced in.

The largest single factor is batch scale. A full panel covering HPLC purity, mass spectrometry identity, proton NMR and residual solvent screening costs the supplier roughly the same amount whether the lot is 10 grams or 10 kilograms, so the per gram cost falls as batch size rises. Synthesis yield and documentation depth explain most of the remaining spread.

Match the lot number on the COA against the lot number printed on the container, then check that a raw chromatogram is attached rather than only a summary purity table. A usable COA also names the analytical method explicitly, states the date of analysis, includes an identity confirmation separate from the purity figure, and names the testing facility. If a supplier will send the certificate but not the trace, treat the purity claim as unverified.

No. Bromantane is not an FDA approved drug product and is supplied strictly for laboratory research, not for human or veterinary consumption. It also appears on the World Anti-Doping Agency Prohibited List as a stimulant, which is relevant to anyone conducting sports science research. Questions about animal health should be directed to a licensed veterinarian rather than a research compound datasheet.

Research grade small molecules including bromantane are commonly specified at 98% or higher by HPLC. The percentage alone tells you very little without the method attached, because area percent measured at a single detection wavelength cannot register impurities that do not absorb at that wavelength. Ask which wavelength was used and whether identity was confirmed separately by mass spectrometry.

Bromantane is a crystalline solid that is stable at room temperature when kept in a sealed, light protected container away from moisture, so it does not require the minus 20 degrees Celsius storage that lyophilised peptides do. Repeated opening exposes the solid to atmospheric moisture, which is why smaller documented lots are often preferable to bulk quantities for gram scale work. Suppliers do not generally issue an open ended shelf life figure for an opened container.

Direct comparison is misleading unless both are normalised to cost per milligram. A 5 mg peptide vial and a 1 gram bottle of bromantane differ by a factor of 200 in mass, so a bromantane price per gram will always look large next to a peptide price per vial. Bromantane also avoids cold chain shipping and reconstitution steps, which removes a cost layer that peptides carry.

It is normally an off white to pale cream crystalline powder. A noticeable colour deviation from a previous lot can indicate residual solvent, oxidative change or a different recrystallisation step in the synthesis route. Appearance is a weak purity indicator in either direction, so the correct response is to compare the current lot COA against the previous one rather than judging by eye.

When a compound is warehoused rather than sourced to order, dispatch typically happens within one business day, and the lot on the shelf is the same lot referenced on the certificate of analysis. Compounds sourced to order introduce a synthesis and testing lead time, which is why quoted delivery windows stretch to weeks with some suppliers. Ask whether stock is on hand before comparing lead times.

For any research programme where reproducibility matters, independent retesting of a small sample is inexpensive relative to the total project cost and settles the purity question permanently. It is most worthwhile when a supplier provides only in house documentation or refuses to release the raw chromatogram. If a supplier already publishes per lot independent laboratory results with matching lot numbers, duplicate testing adds little.

A single certificate of analysis reused across multiple lots. That indicates analytics were never lot linked, which means every purity figure quoted for later batches is an assumption rather than a measurement. Other reliable warning signs include missing lot numbers, purity claims without identity confirmation, and a refusal to name the testing laboratory.

RESEARCH USE ONLY · NOT EVALUATED BY THE FDA