MOTS-c 10mg
MOTS-c peptide is a 16–amino-acid mitochondrial-derived signaling peptide used in preclinical models to probe energy-metabolism, insulin sensitivity, and cellular stress responses. In cell culture and rodent assays, MOTS-c enhances glucose uptake, modulates AMPK pathways, and supports resilience under metabolic stress. Each 10 mg vial is USA-manufactured, HPLC-verified to ≥ 99% purity, endotoxin-screened (< 0.1 EU/mg), and formulated for laboratory research.
⚠️ Important Disclaimer
For Research Use Only. Not for human consumption or therapeutic treatment.
MOTS-c
KEY HIGHLIGHTS
AMPK-Mediated Metabolic Boost
MOTS-c activates AMPK in myocyte and hepatocyte cultures, modeling enhanced glucose uptake and lipid oxidation.
Insulin-Sensitivity Modeling
In rodent insulin-resistance assays, MOTS-c improves insulin signaling markers and glucose-clearance rates.
Mitochondrial Stress Resilience
MOTS-c supports mitochondrial membrane potential and ATP production under oxidative-stress challenges.
Anti-Inflammatory Modulation
Downregulates pro-inflammatory cytokines (TNF-α, IL-6) in macrophage models, offering a tool for inflammation-metabolism crosstalk research.
Longevity-Pathway Engagement
Upregulates genes associated with cellular repair (PGC-1α, Nrf2) in fibroblast assays, aiding studies of aging and resilience.
Lab-Friendly Prep & Storage
Reconstitute MOTS-c in Sterile Water for Injection (SWFI) or Bacteriostatic Water (BAC). Store lyophilized at – 20 °C; keep reconstituted peptide at 2–8 °C for up to 7 days, maintaining ≥ 98% integrity.
What Is MOTS-c Peptide?
MOTS-c (Mitochondrial Open-Reading-Frame of the 12S rRNA-Type c) is a 16–amino-acid peptide encoded within the mitochondrial genome. It acts as a mitochondrial hormone, signaling through AMPK and other metabolic pathways to regulate glucose and lipid homeostasis. In research settings, MOTS-c is applied to cell-culture, organotypic, and in vivo models to explore its role in metabolic health, insulin sensitivity, and cellular stress responses—all without engaging systemic hormone axes.
Why Choose MOTS-c Peptide?
Researchers choose MOTS-c when they need a precise tool for studying mitochondrial-to-nuclear signaling, energy metabolism, and aging-related pathways. Its ability to trigger AMPK activation and downstream gene programs (PGC-1α, Nrf2) makes it ideal for experiments on metabolic syndrome, type-2 diabetes models, and longevity assays. Manufactured in ISO-certified facilities and verified ≥ 99% pure by HPLC—with endotoxin < 0.1 EU/mg—MOTS-c peptide delivers reproducible, high-fidelity data for cutting-edge metabolic research.
What Sets MOTS-c Peptide Apart?
Unlike generic metabolic modulators, MOTS-c is unique as a mitochondrial-derived peptide that directly communicates cellular energy status to nuclear gene programs. Its dual action—enhancing glucose uptake and promoting antioxidant defenses—offers a multi-pathway approach to studying metabolic resilience and aging. With demonstrated stability both lyophilized and in solution, MOTS-c peptide stands out as a next-generation research reagent for dissecting the interplay between mitochondrial health and systemic metabolism.
MOTS-c FAQs
What is MOTS-c peptide?
A 16–amino-acid mitochondrial-derived peptide used to study energy-metabolism, AMPK activation, and insulin sensitivity in research models.
How does MOTS-c activate AMPK?
MOTS-c binds cellular targets to trigger AMPK phosphorylation, enhancing glucose uptake and lipid oxidation in cell assays.
What are the key mots c peptide benefits?
Benefits include improved insulin sensitivity, mitochondrial resilience, metabolic regulation, and anti-inflammatory signaling.
What concentration is typical for MOTS-c studies?
In vitro assays often use 100 nM–10 µM, while in vivo rodent studies range 0.1–1 mg/kg.
Can MOTS-c peptide improve glucose metabolism?
Yes—rodent insulin-resistance models show enhanced glucose-clearance rates and insulin-signaling markers with MOTS-c treatment.
How is MOTS-c peptide reconstituted?
Dissolve in SWFI or BAC water per protocol, then gently mix until fully solubilized.
What storage conditions are required?
Store lyophilized at – 20 °C; keep reconstituted solution at 2–8 °C and use within 7 days.
Does MOTS-c peptide have side effects?
As a research reagent, MOTS-c shows no systemic side effects but must be handled under standard lab-safety protocols.
Can MOTS-c peptide be combined with other peptides?
Yes—frequently co-studied with mitochondrial or metabolic peptides (e.g., SS-31, NAD⁺) for synergistic energy-metabolism research.
Where can I buy MOTS-c peptide online?
Real Peptides offers ISO-certified, USA-manufactured MOTS-c peptide (10 mg) at ≥ 99% purity and low endotoxin—available for research use only.