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99% Pure | USA Finished | Multi Dose | 1000mgNAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell. It carries electrons between reactions and serves as the required substrate for three enzyme families — sirtuins, PARPs, and CD38 — which consume it rather than recycle it. Supplied pre-solubilized at 1000mg in a multi-use format, with no reconstitution step required. Also available as lyophilized powder in vial format.
For Research Use Only. Not for human or veterinary use.
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NAD+ cycles between its oxidized and reduced forms (NAD+/NADH), carrying electrons through glycolysis, the citric acid cycle, and oxidative phosphorylation. This is its best-characterized role and the reason it appears across nearly all of cellular metabolism research.
Sirtuins are NAD+-dependent deacetylases studied in gene regulation and chromatin research. They cannot function without NAD+ — availability of the coenzyme is a rate-limiting factor in sirtuin activity assays.
Poly(ADP-ribose) polymerases consume NAD+ during DNA damage response signaling, making NAD+ availability a variable in DNA repair pathway study designs.
CD38 is an NAD+-consuming ectoenzyme studied in immune signaling and in research on how cellular NAD+ pools are depleted. It is a frequent target in NAD+ metabolism work.
Cells recycle NAD+ through the salvage pathway, converting nicotinamide back into usable coenzyme. This pathway is central to research on how NAD+ pools are maintained and depleted.
Supplied ready-to-use at 1000mg in a multi-use dispenser. No reconstitution step, which eliminates a source of concentration variability between experiments. Store at 2–8°C, protected from light.
NAD+ stands for nicotinamide adenine dinucleotide. It is a coenzyme found in every living cell, and one of the most studied molecules in biochemistry.
Its primary role is electron transfer. NAD+ cycles between an oxidized form (NAD+) and a reduced form (NADH), picking up electrons in one reaction and delivering them in another. That shuttling is what allows glycolysis, the citric acid cycle, and oxidative phosphorylation to proceed — which is why NAD+ appears in essentially every metabolic pathway diagram.
What made NAD+ a subject of intense research over the past two decades is a second role that works differently. Three enzyme families — sirtuins, PARPs, and CD38 — use NAD+ as a consumable substrate rather than a recyclable carrier. They break the molecule apart to do their work. That means these enzymes compete for a finite cellular pool, and it means NAD+ availability becomes a variable in gene regulation, DNA repair, and immune signaling research rather than a constant that can be assumed.
Real Peptides supplies NAD+ pre-solubilized at 1000mg for laboratory research use.
NAD+ appears across an unusually wide span of published literature because it sits at the intersection of two distinct biological roles.
As a redox carrier, it is fundamental to bioenergetics research — any study of cellular bioenergetics involves it. As an enzyme substrate, it is central to work on sirtuins, DNA damage response, and senescence-associated pathways, where the question is not what NAD+ does but how much of it is available and what is consuming it.
That second area is where most current research attention sits. Because sirtuins, PARPs, and CD38 all draw from the same pool, changes in one pathway affect the others — a competition dynamic that makes NAD+ availability a meaningful experimental variable rather than background.
The pre-solubilized format supports consistent concentration control across replicates by removing the reconstitution step. Manufactured in USA facilities and verified to ≥99% purity.
For Research Use Only.
NAD+ is hygroscopic and degrades in solution more readily than many research compounds, which makes handling a real variable in experimental consistency. Every reconstitution introduces an opportunity for concentration error and for exposure to moisture and light.
Supplying it pre-solubilized removes that step. At 1000mg in a multi-use dispenser, the material is prepared once under controlled conditions rather than repeatedly at the bench.
Real Peptides also supplies NAD+ as lyophilized powder in vial format for study designs requiring custom solution concentrations.
| Format | Pre-solubilized solution |
|---|---|
| Strength | 1000mg |
| Presentation | Multi-use dispenser |
| Purity | ≥99% (HPLC) |
| Endotoxin | <0.1 EU/mg |
| Storage | 2–8°C, protected from light, do not freeze |
| Appearance | Clear solution |
| Manufactured | USA |
| Testing | Purity, heavy metals, endotoxins, sterility |
Nicotinamide adenine dinucleotide, a coenzyme present in every living cell. It functions both as an electron carrier in metabolic reactions and as a consumable substrate for sirtuin, PARP, and CD38 enzymes. Supplied by Real Peptides as a laboratory research reagent.
Nicotinamide adenine dinucleotide. The plus sign denotes the oxidized form, which carries a positive charge on its nicotinamide ring. The reduced form is written NADH.
They are the oxidized and reduced forms of the same molecule. NAD+ accepts electrons to become NADH; NADH donates them to become NAD+ again. The ratio between the two is a commonly measured indicator of cellular redox state.
Redox and bioenergetics research, sirtuin enzyme activity, PARP-mediated DNA damage response, CD38 signaling, and salvage pathway regulation in model systems.
Sirtuins are NAD+-dependent deacetylases. They consume NAD+ as a substrate during the deacetylation reaction rather than recycling it, which makes NAD+ availability a rate-limiting factor in sirtuin activity assays.
The route by which cells regenerate NAD+ from nicotinamide, the byproduct left when sirtuins, PARPs, or CD38 consume it. The salvage pathway is the primary mechanism maintaining cellular NAD+ pools.
No. NAD+ is a dinucleotide coenzyme, not a peptide. Real Peptides supplies both peptide and non-peptide research compounds.
NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are precursor molecules that cells convert into NAD+ through the salvage pathway. NAD+ is the coenzyme itself rather than a precursor to it.
Format only. The liquid spray is supplied pre-solubilized at 1000mg; the vial format contains lyophilized powder for study designs requiring custom solution concentrations.
NAD+ is hygroscopic and degrades in solution more readily than many research compounds. Preparing it once under controlled conditions removes a source of concentration variability between experiments.
≥99% by HPLC, independently verified.
At 2–8°C, protected from light. Do not freeze.
Domestic US inventory, typically within 24 hours of order. US shipping only.
No. Supplied strictly as a laboratory research reagent — not a drug, food, cosmetic, or medical device, and not for human or veterinary use.
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