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99% Pure | USA Made | Multi DoseIpamorelin is a pentapeptide GHS-R1a agonist used in preclinical models to stimulate pulsatile growth-hormone release without significant cortisol or prolactin elevation. Ideal for exploring anabolic signaling, IGF-1 activation, and pituitary feedback loops, each 10 mg vial is USA-manufactured, tested to ≥ 99% purity by HPLC, endotoxin-screened (< 0.1 EU/mg), and formulated exclusively for laboratory research.
Peptides are not ready to use. Must purchase BAC water for reconstitution.
Ipamorelin triggers short, predictable GH peaks in rodent and cell-based assays, modeling physiological secretion patterns.
Unlike other secretagogues, Ipamorelin does not significantly raise cortisol or prolactin, ensuring clean GH-axis data.
Downstream IGF-1 upregulation in hepatocyte and muscle-cell cultures supports studies of anabolic and metabolic pathways.
Concentrations from 100 nM to 1 µM define GH-release potency and duration, guiding protocol optimization for in vitro and in vivo studies.
Short-acting pulses let researchers dissect hypothalamic-pituitary feedback loops without prolonged receptor desensitization.
Reconstitute in Sterile Water for Injection (SWFI) or Bacteriostatic Water (BAC); store powder at –20 °C and solution at 2–8 °C for up to 7 days to maintain ≥ 98% integrity.
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) that specifically activates the growth-hormone secretagogue receptor (GHS-R1a), mimicking the natural ghrelin signal to provoke controlled GH release. Unlike broader-spectrum secretagogues, Ipamorelin triggers pulsatile spikes of growth hormone—allowing researchers to model the body’s own hormone rhythms in both cell cultures and animal studies. It is prized for its precise action on the pituitary gland without significant elevation of cortisol or prolactin, making it an ideal reagent for dissecting anabolic pathways, IGF-1 dynamics, and endocrine feedback loops under tightly defined laboratory conditions.
Researchers turn to Ipamorelin when they need a “clean” GH secretagogue that delivers robust growth-hormone surges without off-target hormone effects. Its high specificity for GHS-R1a ensures minimal interference with adrenal or lactotroph axes—so cortisol and prolactin remain stable while GH peaks. This profile makes Ipamorelin perfect for studies of lean-tissue anabolism, metabolic regulation, and receptor-feedback mechanisms. Manufactured under ISO-certified, cGMP-like conditions and verified to ≥ 99% purity by HPLC—with endotoxin < 0.1 EU/mg—each batch provides the consistency and reproducibility critical for hormone-axis and muscle-biology research.
Ipamorelin stands out from other GH-releasing peptides in three key ways:
It binds GHS-R1a with high affinity, triggering only growth-hormone release and avoiding unwanted cascades through cortisol or prolactin pathways.
With a half-life of roughly one hour, Ipamorelin offers researchers tight temporal control over GH pulses, enabling clear mapping of downstream IGF-1 responses and feedback regulation.
Unlike multi-axis secretagogues, Ipamorelin’s “single-axis” profile yields clean data on anabolic signaling without confounding hormone elevations—making it the gold standard for high-resolution endocrine and anabolic-pathway assays.
Together, these attributes make Ipamorelin the go-to research peptide for anyone studying the mechanics of GH release, lean-mass biology, or pituitary feedback with maximum specificity and minimal hormonal “noise.”
Ipamorelin is a synthetic GH-releasing pentapeptide used to study pulsatile growth-hormone release and anabolic pathways in research models.
It acts directly on the GHS-R1a receptor to elicit GH pulses, with minimal cortisol or prolactin elevation, unlike many GHRH agonists.
Commonly used in muscle-anabolism studies, IGF-1 signaling assays, and hypothalamic-pituitary feedback research.
Researchers often employ 100 nM to 1 µM, adjusting based on cell type and desired GH-release profile.
Yes. It’s frequently paired with CJC-1295 No DAC or GHRP-6 to study synergistic GH-axis modulation.
Dissolve in SWFI or BAC water per your lab’s SOP, then gently mix until fully dissolved.
Store lyophilized Ipamorelin at –20 °C; keep reconstituted solutions at 2–8 °C and use within 7 days.
Yes—GH pulses induced by Ipamorelin lead to downstream IGF-1 upregulation in hepatic and muscle assays.
No. Ipamorelin is strictly for research use only and not approved for human or veterinary applications.
Real Peptides offers Ipamorelin made in ISO-certified U.S. labs, HPLC-verified to ≥ 99% purity and endotoxin-screened for reliable research outcomes.
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