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PE-22-28 is a synthetic collagen-fragment peptide designed to jump-start extracellular-matrix and wound-closure pathways in cell cultures and animal models. Each 8 mg vial delivers a stable, ready-to-use peptide that accelerates fibroblast migration and boosts collagen-I synthesis—no extra growth factors required. USA-made, HPLC-verified at ≥ 99% purity, and endotoxin-screened (< 0.1 EU/mg), PE-22-28 brings consistency and speed to your tissue-repair assays every time.
Peptides are not ready to use. Must purchase BAC water for reconstitution.
PE-22-28 speeds movement of dermal fibroblasts in scratch assays, giving clear readouts of wound-closure rates.
Drives elevated procollagen and mature collagen-I levels in skin-cell cultures, modeling extracellular-matrix synthesis.
Improves collagen fibril alignment in 3D tissue constructs, supporting advanced bioengineering studies.
In rodent wound models, PE-22-28 reduces closure time and enhances tensile-strength markers.
Activates TGF-β and SMAD pathways without off-target growth-factor noise, so your data stay focused.
Lyophilized powder—reconstitute in sterile water, store at 2–8 °C, and use within 7 days for consistent activity.
PE-22-28 is an eight-amino-acid fragment derived from collagen’s type I sequence. In the lab, it mimics collagen breakdown signals that naturally trigger fibroblast activation and matrix remodeling—making it a go-to reagent for studying wound-healing, skin regeneration, and extracellular-matrix dynamics.
Choose PE-22-28 when you need a single, targeted peptide to model tissue repair without juggling multiple growth factors. Its direct action on fibroblasts and collagen pathways delivers reproducible wound-closure and ECM-synthesis data, so you can compare treatments, screen biomaterials, or optimize tissue-engineering protocols—all from one vial.
Unlike generic collagen hydrolysates, PE-22-28 offers precise sequence specificity and high receptor affinity, leading to faster fibroblast response and stronger collagen deposition. Its defined fragment length ensures consistent activity and easy integration into both 2D and 3D tissue-model systems.
To study wound closure, collagen-I synthesis, and ECM remodeling in cell and animal models.
By triggering fibroblast migration and collagen-I production via TGF-β/SMAD signaling.
Researchers often use 1–10 µg/mL, adjusted per cell type and assay design.
Yes—it enhances collagen fibril alignment in 3D constructs and tissue explants.
Increased fibroblast migration is seen within 6–12 hours, speeding closure readouts.
Reconstitute in Sterile Water for Injection, gently mix, then use immediately or store at 2–8 °C.
Store powder at –20 °C; use reconstituted solution within 7 days at 2–8 °C.
Its design minimizes off-target effects, focusing on collagen and fibroblast signaling.
No—strictly for research use only, not for therapeutic or veterinary applications.
Real Peptides offers ISO-certified, USA-manufactured PE-22-28 (8 mg), ≥ 99% purity, and low endotoxin—available for research use only.
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