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PT-141 (Bremelanotide) is a lab-grade melanocortin-4 receptor agonist peptide designed for advanced neuromodulation and vascular signaling research. Widely cited in male sexual behavior and penile blood-flow studies, PT-141 offers precise MC4R activation without off-target erythropoietic effects. Each vial is manufactured under ISO-certified conditions, verified to ≥99% purity, and supplied with a full Certificate of Analysis (COA).
Peptides are not ready to use. Must purchase BAC water for reconstitution.
PT-141 is used in lab studies to switch on specific brain receptors (MC4R) that control sexual arousal and autonomic responses—without affecting other hormone systems.
Researchers track how PT-141 changes male mounting behavior, including how often and how quickly animals initiate mating—providing precise, repeatable data on sexual incentive.
In preclinical tests, PT-141 promotes nitric-oxide signaling in blood vessel walls, helping labs study the mechanics of penile blood flow and vascular health.
Lab work shows that single doses of PT-141 (0.1–1.0 mg/kg) become available in the body within minutes, last about 2–3 hours, and maintain measurable effects for up to 6 hours—guiding exactly how and when to dose in protocols.
When scientists give PT-141 alongside testosterone or other steroids, they can dissect how melanocortin and sex-hormone pathways talk to each other—shedding light on complex endocrine networks.
Beyond arousal, PT-141’s impact on general activity and anxiety-related behaviors is assessed in open-field and maze tests—allowing researchers to explore both sexual and mood-related brain circuits.
Labs dissolve PT-141 powder in sterile or bacteriostatic water, freeze it at –20 °C, then keep the reconstituted solution at 2–8 °C for up to a week—ensuring each experiment starts with a fully active, stable peptide.
Each batch of PT-141 undergoes multiple layers of analytical verification to ensure consistent lab performance. Peptide purity is confirmed at ≥99% via high-performance liquid chromatography (HPLC), while peptide sequence integrity is validated through tandem mass spectrometry (MS/MS). Endotoxin levels are certified below 0.1 EU/mg to prevent assay interference, and thermal stability is assessed by Fourier-transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). These quality controls guarantee that every vial delivers reliable, research-grade peptide for sensitive protocol applications.
PT-141 stands out in peptide research for its high selectivity toward melanocortin-4 receptors, enabling precise investigation of neuromodulatory pathways without cross-reactivity in erythropoietic or metabolic receptor systems. Its well-documented use in rodent and non-human primate models provides a robust evidence base for experimental design. Each PT-141 lot is accompanied by a Certificate of Analysis (COA), offering full traceability from synthesis through batch release. Manufactured in ISO-certified U.S. facilities under cGMP-like conditions, PT-141 ensures consistency and compliance for all your laboratory needs.
Unlike broader-acting melanocortin peptides, PT-141 delivers targeted activation of central melanocortin-4 receptors, making it uniquely suited for research into sexual arousal circuitry and vascular function. Its molecular design avoids off-target effects on red blood cell production and systemic metabolism, allowing clear interpretation of neuromodulatory and endothelial endpoints. Coupled with its demonstrated stability in both lyophilized and reconstituted forms, PT-141 offers researchers unparalleled confidence in long-term study reproducibility and data integrity.
Journal of Neuroscience Research. Demonstrated PT-141’s MC4R-mediated increases in male mounting behavior.
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European Journal of Pharmacology. Documented dose-dependent penile blood flow changes in rabbit models.
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Journal of Sexual Medicine. Evaluated PT-141’s effects on erectile function and arousal indices in non-human primates.
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PT-141 is studied for its MC4R-mediated sexual arousal and vascular signaling effects in preclinical models.
Pharmacokinetic studies show a half-life of approximately 2–3 hours in rodent models, with functional effects observed up to 6 hours post-dose.
Preclinical protocols often range from 0.1 to 1.0 mg/kg, depending on species and endpoint metrics.
PT-141 primarily targets MC4R; its effects on testosterone levels are indirect and vary by experimental design.
PT-141 selectively agonizes the melanocortin-4 receptor, modulating CNS pathways linked to sexual arousal and vasodilation.
Yes. Studies have also evaluated PT-141’s effects on female sexual incentive and hormonal responses in rodent assays.
No. PT-141 is strictly for research use only and is not approved for therapeutic applications.
Reconstitute with SWFI or BAC following your lab’s SOPs to achieve the desired concentration.
Store lyophilized peptide at –20 °C; maintain reconstituted solutions at 2–8 °C for up to 7 days.
PT-141 is synthesized in ISO-certified U.S. laboratories, with batch testing for purity, potency, and safety compliance.
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