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Semax nasal spray is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH(4-10), studied in research for cognitive, neuroprotective, and BDNF-modulatory effects. Each 10mg bottle delivers 200mcg per 2-spray actuation, is USA-manufactured, HPLC-verified to ≥99% purity, endotoxin-screened (<0.1 EU/mg), and formulated for laboratory research.
SHIPS: Week Of May 3rd
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Peptides are not ready to use. Must purchase BAC water for reconstitution.
A single intranasal Semax application rapidly increases BDNF, NGF, and TrkB receptor expression in the hippocampus and frontal cortex in rodent models.
Semax improves performance in rat passive-avoidance, conditioned-reflex, and learning assays, often within 15 minutes of intranasal administration.
In rodent cerebral ischemia and photothrombosis models, Semax reduces infarction size and preserves cognitive function post-injury.
Semax modulates monoamine metabolism, potentiates dopaminergic activity, and has been studied as a tool for attention and mood research.
Semax inhibits enzymes involved in enkephalin degradation — a shared property with Selank that supports endogenous opioid pathway research.
Pre-formulated nasal spray — no reconstitution required. Store at 2–8°C, protect from light. Maintains ≥98% integrity throughout shelf life.
Semax is a synthetic seven-amino-acid peptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the 4–10 fragment of adrenocorticotropic hormone (ACTH), with a Pro-Gly-Pro tail added for metabolic stability. Developed at the Russian Academy of Sciences, Semax retains the neurotrophic signaling of ACTH without hormonal activity — making it one of the most extensively studied nootropic peptides in the literature. Semax nasal spray research spans cognitive enhancement, neuroprotection, stroke recovery models, and aging-related cognitive decline.
Researchers choose Semax nasal spray when studying cognitive enhancement, neuroplasticity, BDNF signaling, and recovery from neurological injury. Intranasal delivery is the most documented research route for Semax, with published studies showing BDNF and TrkB elevation within minutes of administration via olfactory pathway uptake. Manufactured in USA facilities and HPLC-verified at ≥99% purity with endotoxin <0.1 EU/mg, Real Peptides Semax nasal spray delivers clean, reproducible experimental data for neuroscience and cognition research.
Semax engages the BDNF/TrkB signaling system directly — rapidly upregulating both the growth factor and its receptor in a single administration. That dual action is what makes Semax a standout research tool for neuroplasticity, learning and memory assays, and ischemic injury models, where downstream effects can be measured within hours rather than days. Many researchers pair Semax with Selank nasal spray to combine nootropic and anxiolytic research endpoints in the same study design.
Semax nasal spray is used in research to study cognitive enhancement, BDNF/NGF signaling, neuroprotection in stroke and ischemia models, and monoamine system modulation. It is a synthetic heptapeptide derived from ACTH(4-10), developed in Russia and supplied by Real Peptides as a 10mg multi-dose nasal spray for laboratory research.
Semax works by rapidly upregulating BDNF (brain-derived neurotrophic factor), NGF (nerve growth factor), and the TrkB receptor in the hippocampus and frontal cortex. It also modulates serotonergic and dopaminergic systems and inhibits enkephalin-degrading enzymes. Research shows these mechanisms produce cognitive enhancement and neuroprotection in preclinical models.
Research has documented five core Semax benefits: (1) rapid BDNF and NGF elevation in the hippocampus, (2) cognitive performance improvements in learning assays within 15 minutes of intranasal administration, (3) neuroprotection in cerebral ischemia models, (4) serotonin and dopamine system modulation, and (5) inhibition of enkephalin degradation supporting endogenous opioid pathway research.
Research shows Semax reaches the central nervous system within 15–30 minutes of intranasal administration via the olfactory pathway. Rodent studies have measured cognitive task improvements 15 minutes after treatment, and BDNF/TrkB elevation is measurable within hours.
Published research reports Semax has a favorable safety profile with minimal adverse effects. The most commonly noted effects in clinical literature are mild transient nasal irritation (intranasal route itself), occasional headache, and rare reports of overstimulation at high doses. Real Peptides Semax is supplied for laboratory research only and is not for human consumption.
No. Semax is not FDA-approved in the United States. It is approved in Russia for stroke, transient ischemic attack, cognitive disorders, and optic nerve indications, and appears on the Russian List of Vital and Essential Drugs. Real Peptides supplies Semax nasal spray strictly for laboratory research use.
Both are Russian-developed heptapeptides with a shared Pro-Gly-Pro stability extension. Semax is derived from ACTH(4-10) and is primarily studied for nootropic and neuroprotective activity. Selank is derived from tuftsin and is primarily studied for anxiolytic and immunomodulatory activity. Researchers frequently pair the two peptides for combined cognitive-anxiolytic study designs.
Semax and N-Acetyl Semax differ in structural stability. N-Acetyl Semax includes an acetyl modification that some research literature describes as providing extended stability in solution. Standard Semax, as supplied by Real Peptides, is the most extensively studied form in the published research literature and is the reference peptide for Semax research protocols.
Yes. Semax is most frequently co-studied with Selank (complementary nootropic-anxiolytic pairing), and across broader cognitive and neurological peptide panels. Its clean BDNF/TrkB mechanism makes it an anchor peptide in neuroplasticity-focused study designs.
Store Semax nasal spray at 2–8°C (refrigerated), protected from light. Do not freeze. When stored correctly, the formulation maintains ≥98% integrity throughout its shelf life.
Real Peptides sells Semax nasal spray in a 10mg multi-dose format, USA-manufactured and HPLC-verified at ≥99% purity. Presale pricing is $200 ($100 off the $300 MSRP), with orders shipping May 3. Browse our full peptide catalog or view popular peptides for related compounds.
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