PEG-MGF is Mechano Growth Factor — the C-terminal E-domain peptide of the IGF-1Ec splice variant — conjugated to polyethylene glycol. The PEG group extends the native peptide's stability, which is measured in minutes in unmodified form. It is supplied as a 2 mg lyophilized vial for laboratory research use only.

How is MGF different from IGF-1?

MGF comes from the same gene as IGF-1 but is a different expression product: mechanical loading shifts splicing toward IGF-1Ec, whose E-domain peptide acts through different signaling than mature IGF-1. Research interest centers on that distinction — particularly its role in satellite-cell activation in muscle-tissue models.

Why is the peptide PEGylated?

Native MGF degrades within minutes in experimental systems. PEGylation — attaching an inert polyethylene-glycol chain — protects the peptide so its activity can be studied over a practical time window. The PEGylated form is the standard in published research for this reason.

What format does PEG-MGF come in?

A single 2 mg lyophilized (freeze-dried) powder in a sealed multi-dose vial. This is the only size offered.

How should PEG-MGF be stored?

Sealed vials should be refrigerated (2–8 °C) and protected from light. Lyophilized peptides are shelf-stable when sealed and stored cold.

Is PEG-MGF for human use?

No. PEG-MGF is sold strictly as a research chemical for in vitro and animal research. It is not a drug, dietary supplement or therapeutic product, and it is not for human consumption or use of any kind.

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Growth Factor & Tissue Signaling Research · Myogenic Peptides

PEG-MGF (PEGylated Mechano Growth Factor) 2 mg for Laboratory Research

~~$96.00~~$48.00Save 50%

PEG-MGF — PEGylated Mechano Growth Factor, supplied as a 2 mg lyophilized vial. MGF is the C-terminal E-domain peptide of the IGF-1Ec splice variant expressed in mechanically loaded muscle tissue; PEGylation extends the native peptide's otherwise minutes-long stability, making it the standard form for satellite-cell and myoblast research. Sold for laboratory research use only.

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PEG-MGF · 2mg

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Pharma-Grade | 2 mg | Lyophilized Vial

PEG-MGF is the PEGylated form of Mechano Growth Factor, the C-terminal peptide of the IGF-1Ec splice variant that muscle tissue expresses in response to mechanical loading. The unmodified peptide is cleared within minutes; conjugating it to polyethylene glycol (PEGylation) extends its stability in solution, which is why the PEGylated form is the standard reference material in this research area.

Researchers use PEG-MGF to study satellite-cell activation, myoblast proliferation and the signaling that distinguishes the MGF E-domain from mature IGF-1, in cell-culture systems such as C2C12 myoblasts and in rodent models of muscle-tissue repair. It is supplied strictly as a research chemical and is not a drug, supplement or therapeutic product.

Real Peptides supplies PEG-MGF as a 2 mg lyophilized powder in a sealed multi-dose vial. Orders ship from Florida and California facilities within 24 hours. For laboratory research use only.

What Is PEG-MGF?

Mechano Growth Factor (MGF) is a splice variant of the IGF-1 gene: when muscle tissue is mechanically loaded or damaged, it transiently expresses IGF-1Ec, whose C-terminal E-domain peptide behaves differently from mature IGF-1. That peptide region is what researchers call MGF. PEG-MGF is the same peptide conjugated to polyethylene glycol — a standard modification that shields the peptide from rapid degradation and extends its usable life in experimental systems from minutes to hours.

Why PEGylation Matters

Unmodified MGF has one of the shortest functional windows of any research peptide: published work places the native peptide's stability at only a few minutes, which makes consistent exposure in cell-culture systems and animal models difficult to standardize. The PEG conjugate resolves that: the same active sequence, protected by an inert polymer, giving researchers a reagent whose activity window can actually be studied. This is why the PEGylated form, not native MGF, is the standard in the literature.

Research Applications

PEG-MGF is used in preclinical work on muscle-tissue biology: satellite-cell activation and proliferation assays, C2C12 myoblast differentiation studies, and rodent models of muscle repair following mechanical injury. Separate preclinical lines have examined MGF-domain signaling in cardiac and neuronal tissue. These are laboratory models — the compound is supplied for in vitro and animal research only, and no human application is implied or supported.

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