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99% Pure | USA Finished | Multi DoseMOTS-c liquid spray is a 16-amino-acid mitochondrial-derived peptide studied in research for AMPK activation, insulin sensitivity, and metabolic-signalling signaling. Real Peptides is the first and only supplier offering MOTS-c in a liquid spray format. Each 25mg / 15mg bottle delivers 200mcg per 2-spray actuation, is USA-manufactured, HPLC-verified to ≥99% purity, endotoxin-screened (<0.1 EU/mg), and formulated for laboratory research.
MOTS-c activates AMP-activated protein kinase (AMPK) in myocyte and hepatocyte cultures, modeling enhanced glucose uptake and lipid oxidation.
Published rodent-model literature reports endogenous MOTS-c expression in skeletal muscle. Supplied as a research reagent; no physiological effect is claimed or implied.
Pre-formulated liquid spray — no reconstitution required, no injection. Store at 2–8°C, protect from light. Maintains ≥98% integrity throughout shelf life.
MOTS-c (Mitochondrial Open-Reading-Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome itself — one of the very few peptides known to originate there rather than in nuclear DNA. First characterized at the USC Leonard Davis School of Gerontology in 2015, MOTS-c acts as a mitochondrial hormone, signaling through AMPK and related metabolic pathways to regulate glucose and lipid homeostasis. Real Peptides is the first supplier to offer MOTS-c in liquid spray format — expanding research access beyond traditional injectable-only protocols.
Researchers study MOTS-c in the context of mitochondrial-to-nuclear signalling and cellular metabolism. Manufactured in USA facilities and verified ≥99% pure by HPLC with endotoxin <0.1 EU/mg. Supplied for laboratory research use only.
MOTS-c is the only widely-studied peptide encoded directly by mitochondrial DNA rather than the nuclear genome — a mitochondrial-derived peptide that functions as a signaling molecule between cellular energy state and nuclear gene expression. This makes it a subject of interest in mitochondrial biology, metabolic signaling, and AMPK-pathway research.
Real Peptides supplies MOTS-c pre-solubilized in a multi-use dispenser, a format that reduces handling loss and reconstitution variability relative to lyophilized vials. It is frequently studied alongside other mitochondrial and metabolic peptides in energy-metabolism research.
For Research Use Only.
MOTS-c is studied in research contexts including mitochondrial signalling, AMPK pathway activity, and gene expression. It is a 16-amino-acid mitochondrial-derived peptide supplied by Real Peptides for laboratory research use only — not for human consumption or therapeutic use.
Published literature describes MOTS-c interaction with the folate cycle and de novo purine biosynthesis, leading to AICAR accumulation and AMP-activated protein kinase pathway activity, with downstream reports of PGC-1α and Nrf2 gene expression. Supplied as a research reagent; no physiological effect is claimed or implied.
Published literature covering MOTS-c includes AMPK pathway activity in myocyte cultures, cellular metabolic signalling in preclinical models, sphingolipid and monoacylglycerol pathway activity, and expression of PGC-1α and Nrf2. These describe published findings only. Real Peptides supplies MOTS-c strictly for laboratory research use — not for human consumption or therapeutic use.
Published studies report endogenous MOTS-c expression in skeletal muscle tissue. These describe published findings in research models only. Real Peptides supplies MOTS-c strictly for laboratory research use — not for human consumption or therapeutic use.
MOTS-c is supplied pre-solubilised in a multi-use dispenser, removing the reconstitution step between experiments. Supplied for laboratory research use only — not for human consumption or therapeutic use.
No. MOTS-c is an investigational research compound and is not FDA-approved in the United States or any other country. Real Peptides supplies MOTS-c liquid spray strictly for laboratory research use only — not for human consumption or therapeutic use.
Peer-reviewed studies in preclinical rodent models have reported changes in sphingolipid and monoacylglycerol pathway activity following MOTS-c exposure. These are third-party published findings in animal models, summarised here for scientific reference only. They are not claims regarding this product and do not describe outcomes in humans. Real Peptides MOTS-c is supplied as a research reagent for laboratory use only.
MOTS-c is unique because it is encoded within mitochondrial DNA rather than the nuclear genome — one of the only known peptides with this origin. This makes it a direct molecular messenger between the mitochondria and the nucleus, giving researchers a precise tool for studying mitochondrial-to-nuclear signaling that other peptides cannot replicate. Compare with our cognitive peptides or browse the full mitochondrial collection.
Each Real Peptides MOTS-c liquid spray bottle contains 45mg of peptide across multiple metered doses. The delivery system provides approximately 200mcg per 2-spray actuation, calibrated for consistent research dosing.
Store MOTS-c liquid spray at 2–8°C (refrigerated), protected from light. Do not freeze. When stored correctly, the formulation maintains ≥98% integrity throughout its shelf life.
Real Peptides is the only supplier offering MOTS-c liquid spray — USA-manufactured, HPLC-verified at ≥99% purity, in a 45mg multi-dose format. Presale pricing is $200 ($100 off the $300 MSRP), with orders shipping May 3. Also see the injectable MOTS-c peptide if your protocol requires that format, or browse mitochondrial research peptides for related compounds.
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