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MOTS-c nasal spray is a 16-amino-acid mitochondrial-derived peptide studied in research for AMPK activation, insulin sensitivity, and exercise-mimetic signaling. Real Peptides is the first and only supplier offering MOTS-c in a nasal spray format. Each 10mg bottle delivers 200mcg per 2-spray actuation, is USA-manufactured, HPLC-verified to ≥99% purity, endotoxin-screened (<0.1 EU/mg), and formulated for laboratory research.
SHIPS: Week Of May 3rd
In Stock, Ready to Ship!
Peptides are not ready to use. Must purchase BAC water for reconstitution.
MOTS-c activates AMP-activated protein kinase (AMPK) in myocyte and hepatocyte cultures, modeling enhanced glucose uptake and lipid oxidation.
In aged and diet-induced obese rodent models, MOTS-c improves insulin signaling markers and glucose-clearance rates — making it a research tool for insulin resistance studies.
Endogenous MOTS-c rises approximately 12-fold in skeletal muscle after exercise. Exogenous MOTS-c administration models overlapping metabolic effects in research settings.
MOTS-c reduces sphingolipid and monoacylglycerol pathway activity in obesity models — pathways typically upregulated in type-2 diabetes and fatty liver research models.
MOTS-c upregulates cellular-repair genes including PGC-1α and Nrf2 in fibroblast assays, supporting research into aging, mitochondrial resilience, and cellular stress response.
Pre-formulated nasal spray — no reconstitution required, no injection. Store at 2–8°C, protect from light. Maintains ≥98% integrity throughout shelf life.
MOTS-c (Mitochondrial Open-Reading-Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome itself — one of the very few peptides known to originate there rather than in nuclear DNA. First characterized at the USC Leonard Davis School of Gerontology in 2015, MOTS-c acts as a mitochondrial hormone, signaling through AMPK and related metabolic pathways to regulate glucose and lipid homeostasis. Real Peptides is the first supplier to offer MOTS-c in nasal spray format — expanding research access beyond traditional injectable-only protocols.
Researchers choose MOTS-c nasal spray when studying mitochondrial-to-nuclear signaling, metabolic syndrome models, insulin resistance, exercise biology, and aging pathways. Until now, MOTS-c research has been limited to subcutaneous or intraperitoneal injection. The Real Peptides MOTS-c nasal spray is the first intranasal MOTS-c research format available anywhere, opening a new non-invasive administration route for studies of central and systemic mitochondrial peptide signaling. Manufactured in USA facilities and verified ≥99% pure by HPLC with endotoxin <0.1 EU/mg.
MOTS-c is the only widely-studied peptide encoded directly by mitochondrial DNA rather than the nuclear genome. That makes it a uniquely direct biological messenger between cellular energy status and nuclear gene programs — essentially, a molecular signal that bridges the cell’s power plant and its command center. Combined with the first-of-its-kind intranasal delivery format, Real Peptides MOTS-c nasal spray is a next-generation research reagent with no competitive equivalent on the market today. It’s commonly studied alongside broader mitochondrial and metabolic peptides in energy-metabolism research.
MOTS-c nasal spray is used in research to study mitochondrial signaling, AMPK pathway activation, insulin sensitivity, exercise-mimetic metabolic effects, and aging-related pathways. It is a 16-amino-acid mitochondrial-derived peptide supplied by Real Peptides as the first-to-market MOTS-c nasal spray for laboratory research.
MOTS-c works by inhibiting the folate cycle and de novo purine biosynthesis, causing AICAR accumulation, which activates AMPK — a central metabolic regulator. Downstream, MOTS-c upregulates PGC-1α and Nrf2 gene programs and improves insulin signaling. Research shows these mechanisms produce exercise-mimetic metabolic effects in preclinical models.
Research has documented five primary MOTS-c research benefits: (1) AMPK activation and enhanced glucose uptake in myocyte cultures, (2) improved insulin sensitivity in aged and diet-induced obese rodent models, (3) exercise-mimetic metabolic signaling, (4) reduced obesity-associated lipid pathway activity, and (5) upregulation of longevity-associated gene programs including PGC-1α and Nrf2.
Endogenous MOTS-c expression in skeletal muscle rises approximately 12-fold after exercise, and exogenous MOTS-c administration in rodent models produces metabolic effects that overlap significantly with exercise training. This is why MOTS-c is frequently described as an exercise-mimetic peptide in the research literature — though it does not replace the cardiovascular or musculoskeletal adaptations of actual exercise.
Yes. Real Peptides is the first and only supplier offering MOTS-c in an intranasal research format. All prior MOTS-c research has been conducted using subcutaneous or intraperitoneal injection. The MOTS-c nasal spray opens a new administration route for research into both central and systemic mitochondrial peptide signaling.
No. MOTS-c is an investigational research compound and is not FDA-approved in the United States or any other country. Real Peptides supplies MOTS-c nasal spray strictly for laboratory research use only — not for human consumption or therapeutic use.
In diet-induced obese rodent models, MOTS-c administration has been shown to reduce body weight, decrease hepatic fat accumulation, and reduce activity of sphingolipid and monoacylglycerol pathways typically upregulated in obesity. These findings describe outcomes observed in research models; Real Peptides MOTS-c nasal spray is supplied for laboratory research only.
MOTS-c is unique because it is encoded within mitochondrial DNA rather than the nuclear genome — one of the only known peptides with this origin. This makes it a direct molecular messenger between the mitochondria and the nucleus, giving researchers a precise tool for studying mitochondrial-to-nuclear signaling that other peptides cannot replicate. Compare with our cognitive peptides or browse the full mitochondrial collection.
Each Real Peptides MOTS-c nasal spray bottle contains 10mg of peptide across multiple metered doses. The delivery system provides approximately 200mcg per 2-spray actuation, calibrated for consistent research dosing.
Store MOTS-c nasal spray at 2–8°C (refrigerated), protected from light. Do not freeze. When stored correctly, the formulation maintains ≥98% integrity throughout its shelf life.
Real Peptides is the only supplier offering MOTS-c nasal spray — USA-manufactured, HPLC-verified at ≥99% purity, in a 10mg multi-dose format. Presale pricing is $200 ($100 off the $300 MSRP), with orders shipping May 3. Also see the injectable MOTS-c peptide if your protocol requires that format, or browse mitochondrial research peptides for related compounds.
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