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$200.00
99% Pure | USA Finished | Multi DoseSemax liquid spray is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH(4-10), studied in research for cognitive, neuroprotective, and BDNF-modulatory effects. Each 45mg bottle delivers 200mcg per 2-spray actuation, is USA-manufactured, HPLC-verified to ≥99% purity, endotoxin-screened (<0.1 EU/mg), and formulated for laboratory research.
Out of stock
Published rodent-model literature reports changes in BDNF, NGF, and TrkB receptor expression in the hippocampus and frontal cortex.
Semax appears in rat passive-avoidance, conditioned-reflex, and learning assay literature.
In rodent cerebral ischemia and photothrombosis models, Semax reduces infarction size and preserves cognitive function post-injury.
Semax modulates monoamine metabolism, potentiates dopaminergic activity, and has been studied as a tool for attention and mood research.
Semax inhibits enzymes involved in enkephalin degradation — a shared property with Selank that supports endogenous opioid pathway research.
Pre-formulated liquid spray — no reconstitution required. Store at 2–8°C, protect from light. Maintains ≥98% integrity throughout shelf life.
Semax is a synthetic seven-amino-acid peptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the 4–10 fragment of adrenocorticotropic hormone (ACTH), with a Pro-Gly-Pro tail added for metabolic stability. Developed at the Russian Academy of Sciences, Semax retains the neurotrophic signalling of ACTH without hormonal activity, and is one of the most extensively studied peptides of its class in the literature. Semax research spans neurotrophic signalling and neuroprotection models. Supplied for laboratory research use only.
Semax appears in published research examining BDNF and TrkB signaling, neurotrophic pathway activity, and melanocortin-receptor mechanisms. Published animal and in-vitro studies have documented BDNF and TrkB elevation in study models under experimental conditions.
Manufactured in USA facilities, HPLC-verified at ≥99% purity, endotoxin-screened at <0.1 EU/mg, and supplied pre-solubilized for reproducible laboratory work. Per-lot COAs available.
For Research Use Only. Not for human or veterinary use.
Semax engages the BDNF/TrkB signaling system directly — rapidly upregulating both the growth factor and its receptor in a single administration. That dual action is what makes Semax a standout research tool for neuroplasticity, learning and memory assays, and ischemic injury models, where downstream effects can be measured within hours rather than days. Many researchers pair Semax with Selank liquid spray to combine nootropic and anxiolytic research endpoints in the same study design.
Semax is studied in research contexts including BDNF/NGF signalling, neuroprotection models, and monoamine system modulation. It is a synthetic heptapeptide derived from ACTH(4-10), developed in Russia and supplied by Real Peptides as a 45mg multi-dose liquid format for laboratory research use only — not for human consumption or therapeutic use.
Published literature describes Semax upregulating BDNF (brain-derived neurotrophic factor), NGF (nerve growth factor), and the TrkB receptor in the hippocampus and frontal cortex, alongside modulation of serotonergic and dopaminergic systems and inhibition of enkephalin-degrading enzymes. Supplied as a research reagent; no physiological effect is claimed or implied.
Published literature covering Semax includes BDNF and NGF expression in the hippocampus, performance measures in rodent learning assays, neuroprotection in cerebral ischemia models, serotonin and dopamine system modulation, and inhibition of enkephalin degradation. These describe published findings only. Real Peptides supplies Semax strictly for laboratory research use — not for human consumption or therapeutic use.
Published research reports Semax reaching the central nervous system within 15–30 minutes in rodent models. Rodent studies have measured task performance changes 15 minutes after treatment, with BDNF/TrkB expression changes measurable within hours. Supplied as a research reagent; no physiological effect is claimed or implied.
Published research reports Semax has a favourable safety profile with minimal adverse effects noted. The most commonly reported observations in the literature are mild transient local irritation, occasional headache, and rare reports of overstimulation at high exposure. Real Peptides Semax is supplied for laboratory research only and is not for human consumption.
No. Semax is not FDA-approved in the United States. It is approved in Russia for stroke, transient ischemic attack, cognitive disorders, and optic nerve indications, and appears on the Russian List of Vital and Essential Drugs. Real Peptides supplies Semax liquid spray strictly for laboratory research use.
Both are Russian-developed heptapeptides with a shared Pro-Gly-Pro stability extension. Semax is derived from ACTH(4-10) and is primarily studied for nootropic and neuroprotective activity. Selank is derived from tuftsin and is primarily studied for anxiolytic and immunomodulatory activity. Researchers frequently pair the two peptides for combined cognitive-anxiolytic study designs.
Semax and N-Acetyl Semax differ in structural stability. N-Acetyl Semax includes an acetyl modification that some research literature describes as providing extended stability in solution. Standard Semax, as supplied by Real Peptides, is the most extensively studied form in the published research literature and is the reference peptide for Semax research protocols.
Yes. Semax is most frequently co-studied with Selank (complementary nootropic-anxiolytic pairing), and across broader cognitive and neurological peptide panels. Its clean BDNF/TrkB mechanism makes it an anchor peptide in neuroplasticity-focused study designs.
Store Semax liquid spray at 2–8°C (refrigerated), protected from light. Do not freeze. When stored correctly, the formulation maintains ≥98% integrity throughout its shelf life.
Real Peptides sells Semax liquid spray in a 45mg multi-dose format, USA-manufactured and HPLC-verified at ≥99% purity. Presale pricing is $200 ($100 off the $300 MSRP), with orders shipping May 3. Browse our full peptide catalog or view popular peptides for related compounds.
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